Grandevity
Grandevity is our cutting-edge Longevity supplement. Once daily, Grandevity activates lonegvity genes! It also reduces oxidative stress, protects cellular functions, improves mitochondrial function, promotes healthy cholesterol levels. Grandevity is made from all-natural, non-GMO ingredients. The choice of ingredients, the purity of the raw materials, and the ingredient ratio lead to a superior Nrf2 activator. It reduces oxidative stress to the level of a child within 30 days.
Additionally, unlike other Nrf2 activators, it activates longevity genes. Grandevity can cross the blood-brain barrier extending its protective effects in the central nervous system. Grandevity addresses all nine cellular and biochemical 'Hallmarks of Aging,' including telomerase activation, which can lengthen telomeres. Additionally, Grandevity can also aid in autophagy, recycling old and damaged cell parts. Grandevity is intimately associated with gene regulation through transcription factors. In essence, Grandevity upregulates the good genes and downregulates the bad genes through epigenetics.
Grandevity dramatically reduces oxidative stress and other longevity genes, turns down pro-inflammatory genes, and supports healthy cholesterol levels by reducing cholesterol synthesis. Scroll down to learn more about Nrf2.
G R A N D E V I T Y
Nrf2 and Longevity
Nrf2 is a protein in all the cells in the body. When activated, it relocates from inside the cell membrane to the nucleus of the cell. There, it attaches to a specific segment of DNA called the Antioxidant Response Element. Genes downstream on the DNA are then upregulated or downregulated. Older Nrf2 technology was known to up-regulate antioxidant enzymes like Superoxide Dismutase, Catalase, and Glutathione. Additionally, there was upregulation of other beneficial genes and downregulation of the production of some harmful proteins such as NF-KB. With newer research, it has been determined that some of the older Nrf2 technologies may cause some detrimental effects on the cells. Enter Grandevity!
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Based on the extensive amount of new, published scientific literature, perhaps the single most significant new area is the “shutdown” part of Nrf2 activation; Nrf2 that is activated by dietary signals remains in the nucleus a little longer and induces more expression of protective genes. Most biochemical systems, in fact, have these types of “on” and “off” pathways running concurrently but at different rates to provide quick response time.
Grandevity, makes use of this expanding knowledge base of Nrf2 activation. We now know that Nrf2 activation consists not only of the Nrf2 transcription factor being released from its inhibitor, migrating into the cell nucleus, and binding to specific DNA sequences that promote cytoprotective gene expression but also of modulating the rate at which Nrf2 is removed from the nucleus. An expanded understanding of the Nrf2 activation process enabled us to develop combinations of dietary agents to achieve improved expression of cytoprotective genes via it and removal pros modulation. The combination of this enhanced knowledge base, along with our new formula, created this Longevity product, Grandevity. Longevity Personalized has been hard at work to bring longevity and Nrf2 supplements to the world, using nature for inspiration, just as technology advances in other areas such as cell phones and technology advances in biochemistry. We are thrilled and excited to be able to share this new technology with the world, which surpasses other Nrf2 products by offering so many different benefits above and beyond the reduction in oxidative stress.
What is Oxidative Stress?
Oxidative stress is rusting of the body from the inside out. A rotting apple is a perfect example of oxidative stress. What causes oxidative stress? Oxidative stress, or oxidation, is a disturbance in the balance between the production of reactive oxygen species and the antioxidant defenses. The foods we eat get "burned" as fuel. There is waste or exhaust associated with this process of making energy for the cells. This "exhaust" or "waste" is the free radicals. These free radicals can damage any part of the cells they contact. What is ROS? Reactive oxygen species, aka free radicals. What are free radicals? Free radicals are toxic reactive molecules that will damage any part of the cell they bump into. Our bodies have a built-in natural defense system. We produce anti-oxidant enzymes which can neutralize those free radicals before the can damage our cells. The Nrf2 pathway senses the need for these antioxidant enzymes and regulates their production to maintain this delicate balance. As we age we produce fewer of these antioxidant enzymes such as superoxide dismutase, catalase, glutathione and others. Nrf2 production declines with age as well. Multiple health conditions and diseases are a direct result of oxidative stress. Infections, allergies, and autoimmune diseases activate our immune cells, which produce free radicals in an attempt to kill germs that the immune system assumes to be present. Unfortunately, our otherwise healthy cells get caught in the cross-fire and sustain collateral damage that we see and feel as inflammation. Other major diseases associated with aging, such as heart disease, stroke, cancer, and neurodegenerative conditions such as Alzheimer’s disease also increase production of free radicals, creating oxidative stress, and inflammation.
Why is Nrf2 Important?
Our DNA encodes about 20,000 genes, each representing a “blueprint” for the production of a protein or enzyme necessary for a healthy existence. Each of these “blueprints” requires a regulating control called a “promoter” that determines precisely how much of each product is produced, and under what circumstances. By binding to one specific type of these switch-like promoter regions called the “Antioxidant Response Element (ARE)” Nrf2 regulates hundreds of different genes that allow cells to survive under stressful conditions. These genes produce antioxidant enzymes that protect the cells by neutralizing free radicals and by helping to repair the damage they have caused.
Grandevity addresses all nine hallmarks of Aging
'Longevity.'
Longevity Coach, Veronica Davis Gordon
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Mark recommended Nrf2 activation to Veronica 7 years ago and she is an excellent example of aging gracefully at 60! A positive mindset, exercise, and nutrition are necessary components to achieve a 'great age' along with natural supplements. Veronica's creative spirit and visionary design led to the name 'Grandevity' to complement and create our lLongevity and Nrf2 activator. She created our bottle design and concept for the website. Mark collaborated with Veronica to share a Cardiologist's perspective on why we all should take a high-quality Nrf2 activator. Mark enjoyed the scientific aspects of our products, and developed the science page and assisted with the website creation. These two often have wonderful ideas and believe their love for one another is their secret potion to a 'long life.' Love is healing too!
How can Nrf2 be Activated?
The Nrf2 protein has the ability to control the expression of genes (epigenetics). The Nrf2 pathway senses and responds to changes in oxidative balance. Nrf2 can be activated when an imbalance is detected. It can then “switch on” or “turn off” the genes it controls (often termed survival genes) to produce the protected state within the cell. Many of the chemical compounds that are Nrf2 activators are produced by certain plants, crude extracts of which were known to our ancestors centuries ago in traditional Chinese, Ayurveda, and Native American medicines. These plant-based compounds (phytochemicals) appear to be just as potent or more potent than, pharmaceutical Nrf2 products products that are beginning to emerge. The power of Grandevity is in the multitude of positive effects it has on multiple longevity genes in addition to its ability to significantly reduce oxidative stress. Nature has a wonderful pharmacy! It has now been discovered that there is a clearer understanding of the pathways on which these plant compounds can exert their positive effects. Natural ingredients can powerfully activate Nrf2. Studies have shown that natural Nrf2 activators are stronger when used together synergistically at activating Nrf2 than several conventional Nrf2 activating drugs. While there are many pharmaceutical agents that have provided humanity with therapies for many health conditions, drugs can, at times, cause significant side effects. Therefore, it's best to keep an open mind and consider all options for lifestyle choices. A life coach can help guide you with good choices when navigating for your wellness. It's nice to know that nature, with the help of an integrative cardiologist, has now given us options for our health.
Ginger
Rosemary
(Carnosol)
Nrf2 declines with age. Grandevity enhances Nrf2 activation to reduce your oxidative stress to the level of a newborn child.
Why You Should Activate Nrf2 ?
Why should we be concerned with supplements or therapeutics that can adjust the Nrf2 pathway? Isn’t it, after all, part of a very large network of interactive and self-regulating pathways that automatically adjust to achieve proper balance based on our metabolism? In a young healthy person, this appears to be the case. After a person is past their reproductive years, however, things begin to change, as Nrf2-activation capabilities decline with age. As harsh as it may sound, after we have passed on our DNA and reared our children we have mostly served our purpose as far as Mother Nature is concerned. While it may not be nice to fool Mother Nature, perhaps people can agree that it’s now acceptable to tinker a little with Mother Nature to help with a 'Long Life'.
Many studies have shown that the concentration of Nrf2 in cells declines as we age. Old age brings with it increased markers of oxidative stress and an assortment of “age-related diseases” such as atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension, Alzheimer's and Parkinson’s diseases, and many others. All of these diseases have at their core increased oxidative stress. By gently stimulating our aging cells’ ability to activate and modulate Nrf2, we aim to restore and enhance our body’s own ability to counteract the effects of oxidative stress so we can live to a 'Great Age'.
TBARS (thiobarbituric acid)—which is a measure of oxidative stress— declines with Nrf2 activation. Elevated TBARS have been associated with a significantly increased risk of cardiac events. TBARS in your body gradually increase as you age, indicating a decrease in Nrf2-regulated pathways and a rise in oxidative stress. TBARS is a marker of the level of oxidative stress in your body. Lowering your TBARS can be very beneficial to your health. Grandevity can support the lowering of TBARS
reducing oxidative stress and activating 'Longevity' genes.
"Live your best life!"
~ Oprah Winfrey
60 is a 'Great Age'. Veronica and Mark Gordon take Grandevity daily to optimize their healthspan and feel good!
"Love is a lesson worth learning."
~ Oprah Winfrey
Explosion in Nrf2 Research
In 2004, there were about 200 papers in the literature on Nrf2 and we were just beginning to paint the picture of Nrf2 as the “master regulator” of the antioxidant response in mammals. Now, in 2023 there are more than 25,000 academic studies have been published, and the title of “master regulator” has proven to be well-deserved. Nrf2, in fact, regulates thousands of genes that have nothing to do with antioxidant enzymes per se, but rather provide protection from a broader range of stress-related events that are encountered by cells, organs, and organisms, under both normal and pathological circumstances. We are now in a much better position to redesign, from the ground up, a new Nrf2 activating dietary supplement based on this massive amount of information learned from published academic research.
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As recently as 2007 Nrf2 activation was thought of in rather simplistic terms—pretty much a one-step process of activating a specific kinase that phosphorylated Nrf2, releasing it to enter the nucleus. The years since then have produced thousands of studies shedding much more light on the intricacies of the pathway. Many of the newly discovered steps in the Nrf2 pathway help us understand the enormity of what this pathway can do in our bodies. Grandevity, supports longevity genes. Older Nrf2 activators do not activate these longevity genes.
Biochemical pathways must be responsive to changing needs and able to sense changing conditions to maintain proper balance. Our current view of the Nrf2 pathway is much more complicated than was appreciated using this knowledge to our advantage; which was a decade ago. Grandevity supports longevity and Nrf2 activation.
GRANDEVITY Activates Longevity Genes
The advancement in science is exciting when technology leads to vast improvements in the products available for us to use daily.
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"Whenever the art of medicine is loved, there is also a love of humanity."
~ Hippocrates
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Longevity Cardiologist, Mark Gordon
Longevity Coach, Veronica Gordon
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It is rewarding when collaboration occurs with teams of like-minded people. Longevity Personalized is delighted to be bringing Grandevity to the world.